Should You be Taking Crestor? What the Crestor Study Really Found.

A recent study was conducted and reported to the media as proving that just about everyone should be taking Crestor because of the way it lowered the incidence of stroke and heart attack.

As usual, when we read the actual study, we find that it said something very different.

The entire study as published in The New England Journal of Medicine is available for free :

“Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein”

Here is a brief summary of how the study was conducted:

The researchers found a group of men over 50 and women over 60 years old who had normal cholesterol but whose C-reactive protein was elevated. C-reactive protein believed to be a marker for inflammation, particularly inflammation in your arteries.

Take a look here to see the other characteristics of the participants in this study:

Baseline Characteristics of the Crestor Study Group

Several things leap out that were not made clear in the popular press reporting of this study.

• First of all, they were older people. The median age was 66. Secondly, though they had normal cholesterol they had other significant risk factors for heart disease and stroke:
• They were overweight. The median BMI was 28.3. That would translate into a weight of 165 lbs for the average 5′ 4″ woman or 192 lbs for the average 5′ 9″ male.
• More importantly, they had higher than normal blood sugars. The median A1c was 5.7% which I have been told by an endocrinologist is high enough to suggest undiagnosed diabetes.
• The interquartile range(a measure of the area in which most values concentrate) for this study group was 5.4% – 5.9%. These figures alone tell us that these people had a higher than normal risk of heart attack since several large studies have shown that the risk of heart attack rises in lock step with the rise of A1c as it goes over 4.7%. At 5.7% the risk is already significantly higher than at true normal.
• Finally, These people had elevated blood pressure–which is another well known pointer to early heart disease. The median blood pressure was 134/80. Doctors now believe 120/80 is the upper bound of normal.

You need to also look at who was excluded from the study:

• Women taking hormone replacement therapy,
• People with any indicator of liver or kidney abnormality,
• People with high blood pressure,
• People with thyroid disease,
• People with autoimmune disease and
• People with a history of alcoholism or drug abuse.

So, why were these people excluded from the study? 

These people were excluded because, among other things, earlier studies have shown that:  Crestor might be very dangerous for them.

Will these same people be excluded from the patients to whom Crestor is prescribed?  Probably not.

The remaining study participants were then put on Crestor, a newer and very expensive statin drug. Note that the study was run exclusively by people with strong financial links to the company that makes Crestor. (More about this at the bottom of this article.)

After two years the study was stopped because it found that people in this group taking Crestor had about half the risk of “end points” than people taking a placebo. These “end points” included were fatal and non fatal myocardial infarction [heart attack], fatal and nonfatal stroke, arterial revascularization [putting in a stent], hospitalization for unstable angina, or confirmed death from cardiovascular causes.

But lets look a bit closer at the statistics. Whenever anyone uses the “Risk” statistic, you can be sure they are trying to amplify a very small statistic into a larger one. Here’s what the actual statistics came up with: There were a total of 393 “end points” reported among the 17,802 people involved in the study. There were a grand total of 109 more “end points” among the people taking placebo compared to those taking Crestor.

In this group of 17,802 people involved in the study, half of whom were taking Crestor, there were 99 heart attacks or 5 per 1,000. Of these 15 were fatal or 8 in 10,000. There were 97 strokes of which 9 were fatal, a rate of 5 in 10,000. These numbers are for the group as a whole.

The most frequent endpoint was getting a stent put in, which occurred in 202 cases or about 1% of the group. When considering this statistic, note that Dr. Davis the cardiologist who writes the Heart Scan Blog believes that this procedure is dramatically overused because there is a strong economic motivator involved: this kind of procedure is the primary way that cardiologists make a living.

It is also worth noting that the way these statistics were collected one person may be recorded as having several “end points” though in fact they had only one incident or hospitalization. In fact, it is worth noting that the way that these end points are reported is so confusing, with so much overlap that it is very hard to know exactly what is being reported. The total given for “primary end points” is much lower than the total of all the various end points listed.

So right away it is important to note that the actual likelihood of death or stroke in this group of middle aged people with clear cardiovascular risk factors, while always regrettable, was still actually quite small.

But no one wants to experience any of these “end points.” So let’s look more closely at what happened when people took 20 mg of Crestor every day for two years.

Though the way the data was reported was carefully arranged to obscure this finding, it appears that while there were indeed slightly less than half as many heart attacks within the group taking Crestor, there were 50% more fatal heart attacks in the group taking Crestor.

The way that this is reported is thus:

Nonfatal myocardial infarction: Crestor 22 Placebo 62
Any myocardial infarction: Crestor 31 Placebo 68

Subtract “Nonfatal myocardial infarctions” from “Any myocardial infarctions” and you get Fatal Myocardial infarctions, a statistic which is NOT reported in the list of “end points.” But simple math gives us the information that there were 9 fatals in the Crestor group as opposed to 6 in the placebo group. That is a 50% higher rate for fatal heart attacks in the Crestor group.

Okay, so it looks like taking Crestor cut down the incidence of heart attack by 37 cases, but did not cut down on the deaths from heart attack. In fact, the proportion of heart attacks that were fatal in the Crestor group was 29% compared to 9% that were fatal in the placebo group.

Why is this not noted by the authors of the study?

In total there were 49 more deaths from any cause in the group taking placebo than in the group taking Crestor, though this statistic is not explained. But it is worth pointing out that the death rate for the study group as a whole (2.5%) was better than the death rate for this age group reported by census data and identical to the death rate for the age group being studied according to CDC statistics.  For stroke, there were 31 fewer strokes in the group taking Crestor and 3 fewer deaths. So Crestor looks a bit more helpful here.

But here’s the other bad news buried in The New England Journal of Medicine study: Both A1c and the incidence of diagnosed diabetes rose in the group taking Crestor.

There were 54 more cases of diabetes diagnosed in the Crestor group than in the placebo group. This is brushed off as barely significant by the authors, though, in fact, it is greater than the difference in heart attack, stroke, etc.

So what does this study tell us about Crestor?

1. Crestor makes a small difference in the cardiovascular health of people with high CRP.

2. This study confirms the suspicion that cholesterol levels are a red herring and that the impact of statins, where they have an impact, is on lowering inflammation in the cardiovascular system.

3. Crestor is more effective against microvascular problems than heart attack death, which makes sense if the main thing they do is decrease inflammation in small arteries most likely to lead to stroke.

4. Crestor lowers the number of heart attacks, but not the number of heart attack deaths.

5. Crestor appears to raise the incidence of diabetes in those taking it. The mechanism of this is not known.

6. The study did not find an increase in muscle or liver problems, but it carfully screened out those who most likely to develop these problems. Crestor has been linked to severe muscle and liver damage. 

7. The study did not investigate or report the incidence of cognitive decline in this group. Statins have been linked to cognitive decline (i.e. memory loss and other signs of dementia).

8. This study did not look at the impact of a much cheaper generic statin on the same endpoints. It was run and reported by people with strong financial links to AstraZeneca, the company that makes the expensive, patented Crestor. It is very possible that the benefits found with Crestor may also be achieved by taking the inexpensive generic statin, Simvastatin (Zocor).

9. This study was run by people with very strong financial links to the manufacturers of Crestor and who have additional financial motives to promote CRP testing. The way that they obscured the heart attack death statistic should make you careful about trusting their conclusions. See the list of conflicts of interest reproduced below.

NOW HERE IS WHY YOU SHOULD BE VERY CAREFUL TRUSTING THIS PUBLISHED NEW ENGLAND JOURNAL OF MEDICINE STUDY

Below is the disclosure paragraph listing the many cited conflicts of interest published with this study. The names listed first are those of the study’s authors.  The names of the pharmaceutical companies financially supporting these doctors and researchers through grants, consulting fees, lecture fees, etc. are listed after each of their names.  It reads like a “Who’s Who” of Giant Pharma:

Dr. Ridker reports receiving grant support from AstraZeneca, Novartis, Merck, Abbott, Roche, and Sanofi-Aventis; consulting fees or lecture fees or both from AstraZeneca, Novartis, Merck, Merck–Schering-Plough, Sanofi-Aventis, Isis, Dade Behring, and Vascular Biogenics; and is listed as a coinventor on patents held by Brigham and Women’s Hospital that relate to the use of inflammatory biomarkers in cardiovascular disease, including the use of high-sensitivity C-reactive protein in the evaluation of patients’ risk of cardiovascular disease. These patents have been licensed to Dade Behring and AstraZeneca. Dr. Fonseca reports receiving research grants, lecture fees, and consulting fees from AstraZeneca, Pfizer, Schering-Plough, Sanofi-Aventis, and Merck; and Dr. Genest, lecture fees from AstraZeneca, Schering-Plough, Merck–Schering-Plough, Pfizer, Novartis, and Sanofi-Aventis and consulting fees from AstraZeneca, Merck, Merck Frosst, Schering-Plough, Pfizer, Novartis, Resverlogix, and Sanofi-Aventis. Dr. Gotto reports receiving consulting fees from Dupont, Novartis, Aegerion, Arisaph, Kowa, Merck, Merck–Schering-Plough, Pfizer, Genentech, Martek, and Reliant; serving as an expert witness; and receiving publication royalties. Dr. Kastelein reports receiving grant support from AstraZeneca, Pfizer, Roche, Novartis, Merck, Merck–Schering-Plough, Isis, Genzyme, and Sanofi-Aventis; lecture fees from AstraZeneca, GlaxoSmithKline, Pfizer, Novartis, Merck–Schering-Plough, Roche, Isis, and Boehringer Ingelheim; and consulting fees from AstraZeneca, Abbott, Pfizer, Isis, Genzyme, Roche, Novartis, Merck, Merck–Schering-Plough, and Sanofi-Aventis. Dr. Koenig reports receiving grant support from AstraZeneca, Roche, Anthera, Dade Behring and GlaxoSmithKline; lecture fees from AstraZeneca, Pfizer, Novartis, GlaxoSmithKline, DiaDexus, Roche, and Boehringer Ingelheim; and consulting fees from GlaxoSmithKline, Medlogix, Anthera, and Roche. Dr. Libby reports receiving lecture fees from Pfizer and lecture or consulting fees from AstraZeneca, Bristol-Myers Squibb, GlaxoSmithKline, Merck, Pfizer, Sanofi-Aventis, VIA Pharmaceuticals, Interleukin Genetics, Kowa Research Institute, Novartis, and Merck–Schering-Plough. Dr. Lorenzatti reports receiving grant support, lecture fees, and consulting fees from AstraZeneca, Takeda, and Novartis; Dr. Nordestgaard, lecture fees from AstraZeneca, Sanofi-Aventis, Pfizer, Boehringer Ingelheim, and Merck and consulting fees from AstraZeneca and BG Medicine; Dr. Shepherd, lecture fees from AstraZeneca, Pfizer, and Merck and consulting fees from AstraZeneca, Merck, Roche, GlaxoSmithKline, Pfizer, Nicox, and Oxford Biosciences; and Dr. Glynn, grant support from AstraZeneca and Bristol-Myers Squibb. No other potential conflict of interest relevant to this article was reported.